Do neurons actually die within 5 minutes of anoxia?

jeudi 27 février 2014

Anoxia is a condition in which there is no delivery of oxygen to tissues of the body. Generally it occurs in cardiac arrest or upon termination of access of air into the lungs. Different tissues have different degrees of resistance to anoxia. It is thought that the least stable are neurons, the cells of the nervous tissue. It is believed that neurons die within 5 minutes of anoxia. Is this true? I have found no indication to direct evidence animal experiments that support this opinion. However I have discovered some facts which indirectly suggest that this view may be erroneous. I propose to discuss these facts.



1. The world record by Tom Sietas. German diver Tom Sietas, competing in Changsha, China have set a new breath-holding world record of 22 minutes and 22 seconds. This was done in front of TV cameras of Chinese television.



2. The event of Fabrice Muamba, a professional footballer from Bolton Wanderers, England. His heart stopped right during the match and did not beat for 78 minutes.



3. Statistical data by American scientists published in their paper



Hallstrom A, Cobb L, Johnson E, Copass M., Cardiopulmonary resuscitation by chest compression alone or with mouth-to-mouth ventilation, New Engl. J. of Med., 2000, Vol. 342, No. 21, 1546-1553.



Analyzing emergency calls because of cardiac arrest, they write that the number of survivors among patients who received only chest compressions higher than among those who received chest compressions and mouth-to-mouth ventilation. They also mention some experimental studies. Characterizing these studies, they write verbatim: "In experimental studies, chest compression alone is associated with survival rates similar to those with chest compression plus mouth-to-mouth ventilation".





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